![]() ![]() Immediate-release orally-disintegrating tablet: Evekeo ODT: Median time d-amphetamine and l-amphetamine 3.5 hours (with water) and 3 hours (without water) increased with food in adultsĮxtended-release orally-disintegrating tablet: Adzenys XR-ODT: Median time d-amphetamine 5 hours (7 hours with food) and l-amphetamine ~5.25 hours (7.75 hours with food)Īdzenys ER suspension: d-amphetamine and l-amphetamine: 5 hours (median) with or without foodĬhildren: Median time d-amphetamine 3.9 hours and l-amphetamine 4.5 hoursĪdults: 4 (2 to 7) hours Duration of Action Immediate-release tablet: Within 4 hours (de la Torre 2004) Urine (30% to 40% unchanged ~50% as metabolites) Time to Peak Hepatic via oxidation, deamination, and CYP2D6 Excretion Oral: Immediate-release tablet: V d: 3 to 4 L/kg (de la Torre 2004) Metabolism Immediate-release orally-disintegrating tablet: Evekeo ODT: C max and AUC comparable to equivalent immediate-release dose Distribution Immediate-release tablet: Rapid (de la Torre 2004) Pharmacokinetics/Pharmacodynamics Absorption The anorexigenic effect is probably secondary to the CNS-stimulating effect the site of action is probably the hypothalamic feeding center. A less significant mechanism may include their ability to block the reuptake of catecholamines by competitive inhibition. Tablet Extended Release Disintegrating, Oral, as base:Īdzenys XR-ODT: 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg Pharmacology Mechanism of ActionĪmphetamines are noncatecholamine sympathomimetic amines that promote release of catecholamines (primarily dopamine and norepinephrine) from their storage sites in the presynaptic nerve terminals. Suspension Extended Release, Oral, as base:ĭyanavel XR: 2.5 mg/mL (464 mL) Įvekeo: 10 mg Įvekeo: 10 mg = Discontinued productĪdzenys ER: 1.25 mg/mL (450 mL) Excipient information presented when available (limited, particularly for generics) consult specific product labeling.
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